Bioactive Follicle-Stimulating Hormone
نویسندگان
چکیده
Specific and sensitive in vitro bioassays suitable for measurement of follicle-stimulating hormone (FSH) in small quantities of serum and urine have recently been validated. Comparisons of bioassay (B-FSH) potencies with immunoassay (I-FSH) estimates and chromatofocusing patterns have facilitated new discoveries regarding the regulation of FSH biosynthesis, storage, secretion, serum concentrations and target cell responsiveness, plasma clearance, and the significance of excreted forms. A review of recent studies reveals that luteinizing hormone and FSH, as well as B-FSH and I-FSH, appear to be differentially regulated by GnRH, GnRH agonists and antagonists, sex steroids and gonadal peptides in both sexes, with significant differences between the sexes. The results support the overall hypotheses that the quality as well as the quantity of FSH are significant contributors to target cell signal transduction and that distinct FSH isoforms with different functional capabilities influence the expression of acute (ovulation) and chronic reproductive events. (Trends Endocrlnol Metab 1991; 2: 145-15 1)
منابع مشابه
The Correlations of Anti-Mullerian Hormone, Follicle-Stimulating Hormone and Antral Follicle Count in Different Age Groups of Infertile Women
متن کامل
Age-Specific Serum Anti-Mullerian Hormone and Follicle Stimulating Hormone Concentrations in Infertile Iranian Women
Background Anti-Müllerian hormone (AMH) is secreted by the granulosa cells of growing follicles during the primary to large antral follicle stages. Abnormal levels of AMH and follicle stimulating hormone (FSH) may indicate a woman’s diminished ability or inability to conceive. Our aim is to investigate the changes in serum AMH and FSH concentrations at different age groups and its correlation w...
متن کاملEvaluation of Ovarian Reserve by Measurement of the Serum Levels of Anti-Mullerian Hormone and Follicle-Stimulating Hormone in Intracytoplasmic Sperm Injection Cycles
Background It is important to evaluate ovarian reserves prior to intracytoplasmic sperm injection (ICSI) treatment. The aim of this study is to determine the accuracy of anti-mullerian hormone (AMH) as a marker for ovarian reserve and to compare it with day-3 serum follicle-stimulating hormone (FSH) levels. MaterialsAndMethods In this analytic, corss-sectional study, sequential sampling was don...
متن کاملCan fasting in the holy month of Ramadan affect on the levels of luteinizing hormone, follicle-stimulating hormone, and prolactin?
Adherence to the recommendations and obligations of Islam is of great importance in achieving a desirable lifestyle. Fasting in the holy month of Ramadan is one of the main principles of Islam, in which Muslims refrain from eating, drinking, oral medications, and smoking from Fajr (pre-dawn) to Maghrib (sunset). Islamic rules dictate that fasting is unacceptable if it causes harm to the health ...
متن کاملP-197: Expression of Bovine Follicle Stimulating Hormone Subunits in Pichia Pastoris
Background: Bovine follicle stimulating hormone (bFSH) belongs to the family of glycoprotein hormones that are released from the pituitary gland or the placenta. This hormone is a heterodimer consisting of common α- and specific β-subunit. Bovine FSH is used for reproductive technology such as superovulation in farm animals and polycystic ovary syndrome treatment. Also this hormone is produced ...
متن کاملAn in vitro Comparative Study of Follicle Stimulating Hormone (FSH) and Activin A Effects on the Maturation of Preantral Follicle-Enclosed Oocytes from Immature Syrian Mice
Objectives: It was aimed to investigate the effects of different doses of follicle stimulating hormone (FSH) and activin A on the growth and maturation of preantral mouse follicles during the in vitro culture. Methods: Preantral follicles (90-100 µm in diameter) were harvested from 6-8 week-old Syrian mice and cultured in TCM199 culture medium for 6 days to see the effect of FSH and Activin A...
متن کامل